81FORMULATION AND IN-VITRO EVALUATION OF FAMOTIDINE BILAYER FLOATING TABLETThe main objective of this investigation was to optimize bilayer gastric floating drug delivery system of Famotidine and to study the effect of formulation variables especially combination of polymers on drug release showing prolonged gastric residence time. The granules were evaluated for the pre compression parameters. The values indicate good flow properties. Tablets were prepared by direct compression method. Tablets were prepared in two stages. First stage was formulation of floating layer tablets & Second stage was formulation of bilayer floating tablet. Both the layers were compressed by using 8mm standard concave punch. In the preliminary trials the behavior of sodium bicarbonate was studied on floating properties, 10% w/w concentration was found to be optimum for floating buoyancy. Hardness of tablet was found 5 kg/cm 2 to be optimum for floating buoyancy of both layers intact. Other post compression parameters were within pharmacopoeial and some non official limit. Percentage drug content in all bilayer floating tablet BFT formulations was found to be 98.47% - 99.96% which was within pharmacopoeial limit. On the basis of buoyancy and in-vitro release kinetics that optimized formulation containing drug-to-total polymer ratio 1:1.5 and HPMC K15M to CP971P 1:1 gave the best invitro release of 99.84% in 12 hrs. FTIR studies show no evidence on interaction betwe en drug, polymers and other excipients. The in vitro data were fitted to different kinetic models.bharattekade@yahoo.co.inResearch512015Gastro retentive floating tablets,Buoyancy,Famotidine,HPMC,Kinetic studiesBharat W. Tekade,Vinod M.Thakare,Umesh T. JadhaoDepartment of Pharmaceutics, TVES’s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, India.,Department of Pharmaceutics, TVES’s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, India.,Department of Pharmaceutics, TVES’s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, India.