83DEVELOPMENT AND VALIDATION OF NEW COLORIMETRIC METHOD FOR THE ESTIMATION OF ALOGLIPTIN & LOTEPREDNOLColorimetric methods have been developed for the estimation of Alogliptin & Loteprednol. Here Methods were based on reaction involving the formation of orange &blue colored complex with NQS(1, 2 napthoquinone -4-sulfonic acid sodium) in the presence of alkaline medium for Alogliptin & Ammonium molibdate in presence of acidic medium for Loteprednol. The maximum absorbance of the solution was measured at 468nm& 745 nm against blank respectively. The calibration curve calculated obeys Beer’s law over the concentration range of 200-600 & 10-50µg/ml.The method was validated based on ICH guidelines. The high recovery and low relative standard deviation confirms the suitability of the method for determination Alogliptin & Loteprednol. Hence it is useful for the routine analysis of Alogliptin&Loteprednol.raval.kashyap99@yahoo.com Research522015Alogliptin,Loteprednol,NaOH,HCL,UV spectrophotometric,Validation ParametersRaval Kashyap,U. SrinivasaResearch Scholar, Department of Pharmacy, Pacific University, Udaipur, Rajasthan, India.,Head of Department, Srinivas College of pharmacy, Mangalore, Karnataka, India.