85NOVEL DRUG DELIVERY SYSTEM FOR AN ANTI-RETROVIRAL DRUG BY USING DIFFERENT POLYMERSTo prepare and evaluate Zidovudine nanoparticles by using different polymers of Eudragit RL 100 and Chitosan by Nano-precipitation method. SEM indicates that nanoparticles have a discrete spherical structure without aggregation. The average particle size was found to be less than1000nm. The particle size of the nanoparticles was gradually increased with increase in the proportion of Eudragit RL100.The drug content, Entrapment efficiency and drug recovery of the nanoparticles was increased vice versa. There is no changes was observed in stability studies in the extent of degradation of product during 3 weeks in which, nanoparticles were stored at various temperatures. FT-IR studies indicated that there was no chemical interaction between drug and polymer and stability of drug. Based on two polymers Eudragit RL100 gives as a good sustain release of the drug with 84%.thejareddy43@gmail.com Research522015Nanoparticles,Nanoprecipitation method,Eudragit RL100,Chitosan,ZidovudineP. Thejaswini,K. Umasankar,P. Jayachandra Reddy,N. SumalathaDept. of Pharmaceutics, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati-517605, Andhra Pradesh, India.,Dept. of Pharmaceutics, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati-517605, Andhra Pradesh, India.,Dept. of Pharmaceutics, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati-517605, Andhra Pradesh, India.,Dept. of Pharmaceutics, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati-517605, Andhra Pradesh, India.